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Bespoke solutions to designing and delivering healthcare research







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Who we are

We have over 20 years combined experience in clinical practice (intensive care, cardiology, general medicine) and academia (Cambridge, Oxford, UCL, Imperial, LSE).

What we do

We conduct research into the application of AI and decision support tools as well as critically reviewing healthcare data for industry and academic partners.

Directors

Photo of Myura Nagendran

Myura Nagendran

I completed my medical degree at Cambridge and Oxford before moving to London in 2013 for postgraduate medical training across a range of acute specialties (MRCP, FRCA, FFICM). I am board certified in intensive care medicine and practise within the NHS having previously also worked in the private sector.

My research has been published in journals including the BMJ, Lancet and Nature Medicine and featured by Fortune and BBC World. I continue to peer-review research and protocols for journals and funders including UK Reasearch and Innovation (UKRI). I was awarded a PhD in 2025 from Imperial College London for my work on clinical AI and the evaluation of explainability in high fidelity simulation settings.

I have consulted for public and private sector clients on projects related to home care monitoring and predictive AI decision support tools. I am also a co-author of DECIDE-AI, a reporting guideline for the early-stage clinical evaluation of AI-driven decision support systems.



Photo of Yang Chen

Yang Chen

I grew up in Dundee, Scotland and studied medicine at Cambridge and Oxford University. Since 2013, I have worked as a medical doctor in London. Alongside my clinical practice in cardiology, I completed an Executive MSc in Health Economics, Outcomes and Management in Clinical Sciences at LSE. Between 2020-2021, I was Chief Registrar at St Bartholomew’s hospital and additionally co-created a management consulting fellowship for clinicians hosted by Deloitte UK.

My recent work has focused on clinical trials integrated within the electronic health record. As principal investigator of the THIRST Alert RCT, I led a team of clinicians and data scientists at UCL and UCLH. I have additionally reviewed research for journals such as the BMJ and the European Heart Journal as well as funders including the Swiss National Science Foundation.

I also consult and draft regulatory documents (FDA, CE, UKCA) for AI software as a medical device (SaMD), and have provided consultation on quality management systems for core lab services in cardiovascular imaging.

Services

We are interested in working on projects where we can offer subject matter expertise to help create bespoke solutions. Our services include:

  • Professional peer review and consultancy for clinical research ideas, trial protocols and business cases
  • Evidence synthesis to Cochrane quality standards for determining the state of the art in a particular field of clinical science
  • Quantitative & qualitative data analysis informed by over 20 years of acute hospital care experience

For more information including examples of our previous work, please get in touch.

Clinical experience

Since 2007, we have worked at over 25 healthcare organisations both nationally and internationally including primary, secondary, tertiary and private care settings. We have extensive experience with electronic health record systems including Cerner and Epic (both as everyday users and for back-end analysis of routinely collected data for service evaluation, quality improvement and research).

  • Clinical medicine is an information processing discipline. Our day to day job involves curating information, interpreting data, problem-solving through hypothesis testing, making evidence-based decisions that respect patient values and communicating them to a wide range of people.

  • In cardiovascular and critical care medicine, we face additional pressures where decision-making is often time pressured, uncertain and with high stakes. Working with teams that continually change has given us a unique perspective on how hospital medicine actually works.

  • We assert - and have experienced - a growing gap between healthcare innovation and real world practice. This led to us building knowledge and skills in health informatics, evidence synthesis and AI design and implementation to complement our clinical practice and bridge this gap.

  • King's College Hospital
  • University College London Hospital
  • St Bartholomew’s Hospital
  • Royal London Hospital
  • St Mary’s Hospital
  • Charing Cross Hospital
  • Hammersmith Hospital
  • Royal Free Hospital
  • Great Ormond Street Hospital
  • Northwick Park Hospital
  • Whipps Cross University Hospital
  • Newham University Hospital
  • Cleveland Clinic London
  • London Nightingale
  • Royal Papworth Hospital - 2008
  • Addenbrookes Hospital - 2009
  • Stoke Mandeville Hospital - 2011-12
  • Royal Berkshire Hospital - 2011-13
  • The Manor Surgery, Oxford - 2011
  • Temple Cowley Health Centre, Oxford - 2011
  • John Radcliffe Hospital - 2011-13
  • Churchill Hospital - 2011-13
  • Nuffield Orthopaedic Centre - 2012
  • Alderhey Hospital - 2012
  • Chinese University Hong Kong Hospital - 2013
  • Auckland City Hospital - 2013
  • Cleveland Clinic Main Campus - 2022

Selected Works

    In 2019, we analysed the documentation of clinical diagnoses by non-consultant clinicians at a large London teaching hospital. In a case note review of 850 de-identified patient assessments, 420 entries only had a single diagnosis recorded. Of these, clinicians did not express uncertainty in the majority of cases. A patient focus day emphasised the importance of research into clinician documentation, particularly given the potential impacts on patient safety. More consistent methods of clinical documentation could improve future diagnostic certainty studies.

Registered company number 15153902.

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